ACTIVATION OF PLATELET MONO-AMINE OXIDASE BY PLASMA IN THE HUMAN

被引:72
作者
YU, PH
BOULTON, AA
机构
基金
英国医学研究理事会;
关键词
D O I
10.1016/0024-3205(79)90486-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A pronounced activation of platelet monoamine oxidase (MAO) by human plasma has been observed. The activation was substrate selective, since serotonin, p-tyramine, dopamine and benzylamine were much more effective than β-phenylethylamine or tryptamine. The activator(s) in the plasma was heat stable but labile to acid hydrolysis and treatment with lipase and protease. The plasma was also found to be capable of activating partially purified MAO obtained from rat liver mitochondria. Phospholipids such as phosphatidylethanolamine were shown to activate MAO. © 1979.
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页码:31 / 36
页数:6
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