METAPHIT FAILS TO ANTAGONIZE PCP-INDUCED PASSIVE-AVOIDANCE DEFICIT

被引：4

作者：

DANYSZ, W

机构：

[1] Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology Sobieskiego 1-9, Warsaw

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 01期

关键词：

METAPHIT; PCP; MK-801; LEARNING; PASSIVE AVOIDANCE; BINDING;

D O I：

10.1016/0091-3057(91)90618-C

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Pretreatment with metaphit (1-[1-(3-isothiocyanotophenyl)cyclohexyl]piperidine), a putative irreversible antagonist of phencyclidine (PCP) receptors, did not antagonize PCP-induced passive avoidance deficit in rats, and did not decrease [H-3]MK-801 (5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine maleate) binding to PCP recognition sites coupled to NMDA receptors. The effectiveness of the metaphit treatment was evidenced by the occurrence of audiogenic seizures. These results suggest that previously reported antagonism in vivo actions of PCP by metaphit, is mediated by sites not involved in PCP-induced passive avoidance deficit, and not related to the NMDA receptor complex in brain structures (striatum, hippocampus, and cortex).

引用

页码：231 / 233

页数：3

共 23 条

[1] THE DISSOCIATIVE ANESTHETICS, KETAMINE AND PHENCYCLIDINE, SELECTIVELY REDUCE EXCITATION OF CENTRAL MAMMALIAN NEURONS BY N-METHYL-ASPARTATE [J].

ANIS, NA ;

BERRY, SC ;

BURTON, NR ;

LODGE, D .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (02) :565-575

[2] METAPHIT, A RECEPTOR ACYLATOR, INACTIVATES COCAINE BINDING-SITES IN STRIATUM AND ANTAGONIZES COCAINE-INDUCED LOCOMOTOR STIMULATION IN RODENTS [J].

BERGER, P ;

JACOBSEN, AE ;

RICE, KC ;

LESSOR, RA ;

REITH, MAE .

NEUROPHARMACOLOGY, 1986, 25 (08) :931-933

[3] ACYLATION OF SIGMA-RECEPTORS BY METAPHIT, AN ISOTHIOCYANATE DERIVATIVE OF PHENCYCLIDINE [J].

BLUTH, LS ;

RICE, KC ;

JACOBSON, AE ;

BOWEN, WD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 161 (2-3) :273-277

[4] ROLE OF THE AROMATIC GROUP IN THE INHIBITION OF PHENCYCLIDINE BINDING AND DOPAMINE UPTAKE BY PCP ANALOGS [J].

CHAUDIEU, I ;

VIGNON, J ;

CHICHEPORTICHE, M ;

KAMENKA, JM ;

TROUILLER, G ;

CHICHEPORTICHE, R .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (03) :699-705

[5]

CHICHEPORTICHE R, 1988, SIGMA PHENCYCLIDINE, P107

[6] A SPECIFIC ALKYLATING LIGAND FOR PHENCYCLIDINE (PCP) RECEPTORS ANTAGONIZES PCP BEHAVIORAL-EFFECTS [J].

CONTRERAS, PC ;

RAFFERTY, MF ;

LESSOR, RA ;

RICE, KC ;

JACOBSON, AE ;

ODONOHUE, TL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 111 (03) :405-406

[7]

CONTRERAS PC, 1986, J PHARMACOL EXP THER, V238, P1101

[8]

DANYSZ W, 1989, NEUROSCI RES COMMUN, V5, P9

[9] IS METAPHIT A PHENCYCLIDINE ANTAGONIST - STUDIES WITH KETAMINE, PHENCYCLIDINE AND N-METHYLASPARTATE [J].

DAVIES, SN ;

CHURCH, J ;

BLAKE, J ;

LODGE, D ;

LESSOR, RA ;

RICE, KC ;

JACOBSON, AE .

LIFE SCIENCES, 1986, 38 (26) :2441-2445

[10] METAPHIT, AN ISOTHIOCYANATE ANALOG OF PCP, INDUCES AUDIOGENIC-SEIZURES IN MICE [J].

DEBLER, EA ;

LIPOVAC, MN ;

LAJTHA, A ;

ZLOKOVIC, BV ;

JACOBSON, AE ;

RICE, KC ;

REITH, MEA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 165 (01) :155-159

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