DRUGS EFFECTS ON SUPEROXIDE GENERATION AND CHEMILUMINESCENCE RESPONSE OF HUMAN-LEUKOCYTES

被引：17

作者：

PASCUAL, C

GONZALEZ, R

ROMAY, C

机构：

[1] Centro Nacional de Investigaciones Científicas (CENIC), Ciudad de la Habana, Cubanacan, Playa

来源：

AGENTS AND ACTIONS | 1991年 / 32卷 / 3-4期

关键词：

D O I：

10.1007/BF01980886

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Luminol-enhanced chemiluminescence was used to determine the effects of diethyldithiocarbamate, dipyridamole, catechin and verapamil on the generation of reactive oxygen species in human leukocytes, and on superoxide generated by chemiluminescence of the hypoxanthine xanthine-oxidase reaction. These agents reduced the luminol enhanced chemiluminescence response of activated leukocytes, most probably by inhibiting the superoxide generation reaction. On the other hand, citrate and diethylcarbamazine, produced a slight increase of the luminol enhanced chemiluminescence of leukocytes.

引用

页码：277 / 282

页数：6

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