ADRENERGIC-STIMULATION OF MEMBRANE-PROTEIN PHOSPHORYLATION IN HUMAN-ERYTHROCYTES

被引：14

作者：

NELSON, MJ

FERRELL, JE

HUESTIS, WH

机构：

[1] Department of Chemistry, Stanford University, Stanford

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 558卷 / 01期

基金：

美国国家卫生研究院;

关键词：

(Erythrocyte); Adrenergic modification; Noradrenalin; Protein phosphorylation;

D O I：

10.1016/0005-2736(79)90323-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenergic modification of membrane protein phosphorylation was studied in intact human erythrocytes. Micromolar norepinephrine increased 32P incorporation into Band 2 by 70%, and into Band 3 by 40%. Phosphorylation levels observed with a series of specific agonists and antagonists suggest that an α-adrenergic receptor is involved in this effect. The mechanism of linkage between this receptor and protein phosphorylation does not appear to involve modulation of intracellular concentrations of ATP, cyclic AMP, or cyclic GMP. © 1979.

引用

页码：136 / 140

页数：5

共 25 条

[1] HUMAN RED BLOOD CELLS - PROSTAGLANDIN-E2, EPINEPHRINE, AND ISOPROTERENOL ALTER DEFORMABILITY [J].