COMPARATIVE EFFECT OF 6S, 6R AND 6RS LEUCOVORIN ON METHOTREXATE RESCUE AND ON MODULATION OF 5-FLUOROURACIL

被引：15

作者：

ZITTOUN, J

MARQUET, J

PILORGET, JJ

TONETTI, C

DEGIALLULY, E

机构：

[1] HOP HENRI MONDOR,FAC MED,SERV CENT HEMATOL IMMUNOL,F-94010 CRETEIL,FRANCE

[2] HOP HENRI MONDOR,SERV REANIMAT MED,F-94010 CRETEIL,FRANCE

来源：

BRITISH JOURNAL OF CANCER | 1991年 / 63卷 / 06期

关键词：

D O I：

10.1038/bjc.1991.194

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The comparative efficacy of the pure diasteroisomers of leucovorin, the natural (6S) and the unnatural (6R) forms was compared to the racemic form (6RS). A protective effect in methotrexate-treated CCRF-CEM cells was obtained with 6S at concentrations 100-fold higher than those of methotrexate and with 6RS at concentrations 2-fold greater than those of 6S; however, at low concentrations of methotrexate, 6S was more effective than 6RS in preventing the cytotoxicity of methotrexate; on the opposite, 6R exhibited a protective effect at concentrations 10(4) higher than those of methotrexate. On the same cell line, 6S was shown to enhance the cytotoxic effect of 5 Fluorouracil exactly as 6RS while 6R did not exhibit any enhancing effect on cells exposed to 5 Fluorouracil.

引用

页码：885 / 888

页数：4

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