LOCAL PERINEAL IMPLANTS OF ANTIANDROGEN BLOCK MASCULINIZATION OF THE SPINAL NUCLEUS OF THE BULBOCAVERNOSUS

被引：42

作者：

FISHMAN, RB

BREEDLOVE, SM

机构：

[1] UNIV CALIF BERKELEY,DEPT PSYCHOL,3210 TOLMAN HALL,BERKELEY,CA 94720

[2] UNIV CALIF BERKELEY,DEPT PSYCHOL,GRAD GRP NEUROBIOL,BERKELEY,CA 94720

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1992年 / 70卷 / 02期

关键词：

HYDROXYFLUTAMIDE; MASCULINIZATION; BULBOCAVERNOSUS MOTONEURON;

D O I：

10.1016/0165-3806(92)90208-E

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Female rats were injected with testosterone propionate on the 1st and 3rd days of life. In addition, some females received 200 mug of the anti-androgen, hydroxyflutamide. Females receiving anti-androgen directly to the perineum, including the muscles bulbocavernosus and levator ani, had fewer surviving spinal nucleus of the bulbocavernosus (SNB) motoneurons than did females receiving the anti-androgen systemically. These results indicate that androgen acts upon the target muscles to spare developing SNB motoneurons from death.

引用

页码：283 / 286

页数：4

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