EFFECT OF LOADING CONDITIONS ON DOPPLER-DERIVED TRANSMITRAL FLOW INDEXES IN NORMAL SUBJECTS AND PATIENTS WITH CORONARY-ARTERY DISEASE

被引：4

作者：

TAK, T ^{[1
]}

CHOUDHARY, RS ^{[1
]}

CHATTERJEE, S ^{[1
]}

WIDERHORN, J ^{[1
]}

RAHIMTOOLA, SH ^{[1
]}

CHANDRARATNA, PAN ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT MED,CARDIOL SECT,LOS ANGELES,CA 90089

来源：

ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES | 1992年 / 9卷 / 05期

关键词：

ECHOCARDIOGRAPHY; DOPPLER; ULTRASOUND; CORONARY ARTERY DISEASE; TRANSMITRAL DOPPLER VELOCITY; DIASTOLIC INFLOW;

D O I：

10.1111/j.1540-8175.1992.tb00489.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of alterations in preload and afterload on left ventricular diastolic filling using echocardiography was examined in nine normal volunteers (NLS) and nine patients (PTS) with coronary artery disease. The sequential interventions used were handgrip to increase afterload, nitroglycerin to decrease preload, and nifedipine to decrease afterload. Transmitral flow was measured using pulsed-Doppler echocardiography. Measurements were made pre- and post interventions. With increase in afterload using handgrip, the A and E wave velocities and the A/E ratio increased in both groups: 0.62 +/- 0.14 versus 0.86 +/- 0.17 in NLS; 0.75 +/- 0.45 versus 0.84 +/- 0.50 in PTS (P < 0.05). Following administration of nitroglycerin to reduce preload, the A wave velocities increased, the E wave velocity decreased in both groups, and the A/E ratio increased 0.57 +/- 0.11 versus 0.67 +/- 0.13 in NLS; 0.78 +/- 0.40 versus 0.91 +/- 0.44 in PTS (P < 0.05). Following use of nifedipine, the A and E wave velocities decreased in both groups with an increase in the A/E ratio in the patient group 0.83 +/- 0.13 versus 0.89 +/- 0.11 (P = NS). Thus, both normal subjects and patients with coronary artery disease had similar changes in Doppler-derived indices of left ventricular filling following interventions that changed left ventricular preload and afterload.

引用

页码：467 / 474

页数：8

共 15 条

[1]

Kitabatake A, Inoue M, Asao M, Et al., Transmitral blood flow reflecting diastolic behavior of the left ventricle in health and disease: A study by pulsed Doppler technique, Jpn Circ J, 46, (1982)

[2]

Grossman W, McLaurin LP, Diastolic properties of the left ventricle, Ann Intern Med, 84, (1976)

[3]

Harizi RC, Bianco JA, Alpert JS, Diastolic function of the heart in clinical cardiology, Arch Intern Med, 148, (1988)

[4]

Spirito P, Maron BJ, Verter I, Et al., Reproducibility of Doppler echocardiographic measurements of left ventricular diastolic function, Eur Heart J, 9, (1988)

[5]

Appleton CP, Hatle LK, Popp RL, Relation of transmitral flow velocity patterns to left ventricular diastolic function: New insights from a combined hemodynamic and Doppler echocardiographic study, J Am Coll Cardiol, 12, (1988)

[6]

Lin SL, Tak T, Kawanishi D, Et al., Comparison of Doppler echocardiographic and hemodynamic indexes of left ventricular diastolic properties in coronary artery disease, Am J Cardiol, 62, (1988)

[7]

Phillips RA, Coplan NL, Krakoff LR, Et al., Doppler echocardiographic analysis of left ventricular filling in treated hypertensive patients, J Am Coll Cardiol, 9, (1987)

[8]

Miller TR, Grossman SJ, Schectman KB, Et al., Left ventricular diastolic filling and its association with age, Am J Cardiol, 58, (1986)

[9]

Choong CY, Herrmann HC, Weyman AE, Et al., Preload dependence of Doppler‐derived indexes of left ventricular diastolic function in humans, J Am Coll Cardiol, 10, (1987)

[10]

Choong CY, Abascal VM, Thomas JD, Et al., Combined influence of ventricular loading and relaxation on the transmitral flow velocity profile in dogs measured by Doppler echocardiography, Circulation, 78, (1988)

← 1 2 →