MURINE HOX-1.11 HOMEOBOX GENE STRUCTURE AND EXPRESSION

被引：58

作者：

TAN, DP ^{[1
]}

FERRANTE, J ^{[1
]}

NAZARALI, A ^{[1
]}

SHAO, XP ^{[1
]}

KOZAK, CA ^{[1
]}

GUO, V ^{[1
]}

NIRENBERG, M ^{[1
]}

机构：

[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 14期

关键词：

HOX-1.11 NUCLEOTIDE SEQUENCE; EMBRYONIC DEVELOPMENT;

D O I：

10.1073/pnas.89.14.6280

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hox-1.11 gene encodes a protein 372 amino acid residues long that contains a conserved pentapeptide, a homeodomain, and an acidic region. The amino acid sequence of the homeodomain of Hox-1.11 is identical to that of Hox-2.8, and the N-terminal and C-terminal regions of Hox-1.11 are similar to those of human HOX2H, which is the equivalent of murine Hox-2.8. The Hox-1.11 gene was shown to reside on murine chromosome 6, which contains the Hox-1 cluster of homeobox genes. One species of Hox-1.11 poly(A)+ RNA approximately 1.7 kb long was detected in mouse embryos, which is most abundant in 12-day-old embryos and progressively decreases during further embryonic development. The most anterior expression of Hox-1.11 poly(A)+ RNA in 12- to 14-day-old mouse embryos was shown by in situ hybridization to be in the mid and posterior hindbrain. Hox-1.11 poly(A)+ RNA also is expressed in the VII and VIII craniaL ganglia, spinal cord, spinal ganglia, larynx, lungs, vertebrae, sternum, and intestine.

引用

页码：6280 / 6284

页数：5

共 27 条

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