THE REGULATION OF EMPTY SPIRACLES BY ABDOMINAL-B MEDIATES AN ABDOMINAL SEGMENT IDENTITY FUNCTION

被引:67
作者
JONES, B [1 ]
MCGINNIS, W [1 ]
机构
[1] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06511
关键词
EMPTY SPIRACLES; ABDOMINAL-B; DROSOPHILA; HOMEOTIC; HOMEO DOMAIN;
D O I
10.1101/gad.7.2.229
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The empty spiracles (ems) homeo box gene is required for the development of the Drosophila larval filzkorper, which are structural specializations of the eighth abdominal segment. Filzkorper development is also dependent on the function of the homeotic selector gene Abdominal-B (Abd-B). Here, we show that ems is a downstream gene that is transcriptionally regulated by Abd-B proteins. This regulation is mediated by an Abd-B-dependent ems cis-regulatory element that in early- to mid-stage embryos is activated only in the eighth abdominal segment. Genetic epistasis tests suggest that both ems and Abd-B are required in combination for the specification of the filzkorper primordia. In a general sense, these results also provide evidence that the hierarchical level immediately downstream of the homeotic genes contains additional homeo domain transcription factors that define subsegmental domain identities.
引用
收藏
页码:229 / 240
页数:12
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