KINETIC-BEHAVIOR OF ZYMOGEN ACTIVATION PROCESSES IN THE PRESENCE OF AN INHIBITOR

被引：7

作者：

VARON, R ^{[1
]}

MANJABACAS, MC ^{[1
]}

GARCIAMORENO, M ^{[1
]}

VALERO, E ^{[1
]}

GARCIACANOVAS, F ^{[1
]}

机构：

[1] UNIV MURCIA, FAC VET, DEPT BIOQUIM & BIOL MOLEC, E-30100 ESPINARDO, SPAIN

来源：

BIOCHEMICAL JOURNAL | 1993年 / 290卷

关键词：

D O I：

10.1042/bj2900463

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A global kinetic analysis of a general zymogen activation model, where not only the activating but also the activated enzyme suffer an irreversible inhibition is presented. A reaction in which the enzyme acts upon a substrate is coupled to monitor the process. In addition, we determined the corresponding kinetic equations for a number of particular cases of the general model studied, Finally, a kinetic data analysis and a procedure to discriminate among the different mechanisms considered, which are based on the kinetic equations obtained, are suggested.

引用

页码：463 / 470

页数：8

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