ANALYSIS OF CELL-POPULATIONS IN RHEUMATOID-ARTHRITIS SYNOVIAL TISSUES

被引：45

作者：

YANNI, G

WHELAN, A

FEIGHERY, C

BRESNIHAN, B

机构：

[1] ST VINCENTS HOSP, DEPT RHEUMATOL, ELM PK, DUBLIN 4, IRELAND

[2] ST JAMES HOSP, DEPT IMMUNOL, DUBLIN 8, IRELAND

来源：

SEMINARS IN ARTHRITIS AND RHEUMATISM | 1992年 / 21卷 / 06期

关键词：

RHEUMATOID ARTHRITIS; IMMUNOHISTOLOGY; SYNOVIAL MEMBRANE;

D O I：

10.1016/0049-0172(92)90040-K

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains. © 1992.

引用

页码：393 / 399

页数：7

共 26 条

[1]

AKBAR AN, 1988, J IMMUNOL, V140, P2171

[2] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[3]

BARLAND P, 1962, ARTHRITIS RHEUM, V9, P589

[4] DEFICIENCY OF THE SUPPRESSOR INDUCER SUBSET OF LYMPHOCYTES-T IN RHEUMATOID-ARTHRITIS [J].

EMERY, P ;

GENTRY, KC ;

MACKAY, IR ;

MUIRDEN, KD ;

ROWLEY, M .

ARTHRITIS AND RHEUMATISM, 1987, 30 (08) :849-856

[5] CHANGES IN VASCULAR ENDOTHELIUM RELATED TO LYMPHOCYTE COLLECTIONS IN DISEASED SYNOVIA [J].

FREEMONT, AJ ;

JONES, CJP ;

BROMLEY, M ;

ANDREWS, P .

ARTHRITIS AND RHEUMATISM, 1983, 26 (12) :1427-1433

[6] T-CELL IMMUNOREGULATION IN RHEUMATOID SYNOVITIS [J].

GERLI, R ;

BERTOTTO, A ;

RAMBOTTI, P ;

BARBIERI, P ;

CIOMPI, ML ;

BOMBARDIERI, S .

ARTHRITIS AND RHEUMATISM, 1988, 31 (08) :1075-1076

[7] ULTRASTRUCTURE OF RABBIT SYNOVIAL MEMBRANE [J].

GHADIALLY, FN ;

ROY, S .

ANNALS OF THE RHEUMATIC DISEASES, 1966, 25 (04) :318-+

[8] MECHANISMS OF DISEASE - RHEUMATOID-ARTHRITIS - PATHOPHYSIOLOGY AND IMPLICATIONS FOR THERAPY [J].

HARRIS, ED .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (18) :1277-1289

[9] ELECTRON-MICROSCOPIC STUDY OF RHEUMATOID SYNOVIAL VASCULATURE - INTIMATE-RELATIONSHIP BETWEEN TALL ENDOTHELIUM AND LYMPHOID AGGREGATION [J].

IGUCHI, T ;

ZIFF, M .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (02) :355-361

[10] ELECTRON-MICROSCOPIC OBSERVATIONS OF IMMUNOREACTIVE CELLS IN RHEUMATOID SYNOVIAL MEMBRANE [J].

ISHIKAWA, H ;

ZIFF, M .

ARTHRITIS AND RHEUMATISM, 1976, 19 (01) :1-14

← 1 2 3 →