UP-REGULATION OF COMPLEMENT REGULATORS MCP (CD46), DAF (CD55) AND PROTECTIN (CD59) IN ARTHRITIC JOINT DISEASE

被引:30
作者
DAVIES, ME [1 ]
HORNER, A [1 ]
LOVELAND, BE [1 ]
MCKENZIE, IFC [1 ]
机构
[1] AUSTIN RES INST,HEIDELBERG,VIC,AUSTRALIA
关键词
INFLAMMATORY JOINT DISEASE; COMPLEMENT REGULATORY PROTEINS; CHONDROCYTES;
D O I
10.3109/03009749409099280
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CD46, CD55 and CD59 are cell surface glycoproteins which are widely distributed on normal tissue, where they function in the prevention of complement-mediated damage. In this study we have investigated the altered expression of these molecules under inflammatory conditions both in vitro and in vivo. By using immunocytochemical techniques we demonstrated marked but disparate upregulation of these molecules in IL1-treated cartilage and in diseased cartilage from arthritic joints compared to normal cartilage in both humans and pigs. Expression of these proteins was restricted to the chondrocyte surface, and was also demonstrated on isolated chondrocytes grown in monolayer culture and stimulated with IL1. It is suggested that the elevated levels of these regulatory proteins may be necessary to ameliorate the multiple damaging effects of the inflammatory processes associated with destructive joint diseases.
引用
收藏
页码:316 / 321
页数:6
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