INCREASED LEVELS OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 IN MULTIPLE-SCLEROSIS AND HUMAN T-LYMPHOTROPIC VIRUS TYPE-I ASSOCIATED MYELOPATHY

被引：57

作者：

TSUKADA, N ^{[1
]}

MIYAGI, K ^{[1
]}

MATSUDA, M ^{[1
]}

YANAGISAWA, N ^{[1
]}

机构：

[1] SHINSHU UNIV,SCH MED,DEPT NEUROL,MATSUMOTO,NAGANO 390,JAPAN

来源：

ANNALS OF NEUROLOGY | 1993年 / 33卷 / 06期

关键词：

D O I：

10.1002/ana.410330614

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the presence of soluble intercellular adhesion molecule-1 (sICAM-1) antigen in the sera of patients with multiple sclerosis and human T-lymphotropic virus type 1 (HTLV-I)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay. Patients with multiple sclerosis in the active phase had higher sICAM serum levels than did control subjects (p < 0.01). In addition, a significantly increased serum level of sICAM-1 was found in patients with HAM (p < 0.001). Furthermore, we found a positive correlation with HAM sICAM-1 and tumor necrosis factor-alpha levels in the sera of patients with multiple sclerosis in the active phase (r = 0.88, p < 0.01) and in those with HAM (r = 0.86, p < 0.0 1). These results suggest that serum sICAM-1 may be related to clinical activity in patients with multiple sclerosis and the detection of sICAM-1 could be useful as a marker of inflammatory disease.

引用

页码：646 / 649

页数：4

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