ANTIVIRAL ACTIVITY OF A SULFATED POLYSACCHARIDE FROM THE RED SEAWEED NOTHOGENIA-FASTIGIATA

被引：62

作者：

DAMONTE, E

NEYTS, J

PUJOL, CA

SNOECK, R

ANDREI, G

IKEDA, S

WITVROUW, M

REYMEN, D

HAINES, H

MATULEWICZ, MC

CEREZO, A

COTO, CE

DECLERCQ, E

机构：

[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM ORGAN,RA-1428 BUENOS AIRES,ARGENTINA

[2] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 47卷 / 12期

关键词：

SULFATED POLYMERS; ANTIVIRAL; HIV; HCMV; HSV; INFLUENZA VIRUS;

D O I：

10.1016/0006-2952(94)90254-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antiviral activity of polysaccharide fractions obtained from water extracts of the red seaweed Nothogenia fastigiata was investigated. Fraction F6, corresponding to a sulphated xylomannan, was found to inhibit efficiently the replication of herpes simplex virus type 1 (HSV-1). Furthermore, F6 selectively inhibited the replication of several other enveloped viruses including herpes simplex virus type 2, human cytomegalovirus (HCMV), respiratory syncytial virus, influenza A and B virus, Junin and Tacaribe virus and simian immunodeficiency virus. F6 was only weakly active against human immunodeficiency virus type 1 and 2. The mode of action of F6 against HSV-1 and HCMV could be ascribed to an inhibitory effect on virus adsorption.

引用

页码：2187 / 2192

页数：6

共 26 条

[1] PENTOSAN POLYSULFATE, A SULFATED OLIGOSACCHARIDE, IS A POTENT AND SELECTIVE ANTI-HIV AGENT INVITRO [J].