AROMATIC AMINO-ACID PHOSPHORAMIDATE DIESTERS AND TRIESTERS OF 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) ARE NONTOXIC INHIBITORS OF HIV-1 REPLICATION

被引：55

作者：

WAGNER, CR ^{[1
]}

MCINTEE, EJ ^{[1
]}

SCHINAZI, RF ^{[1
]}

ABRAHAM, TW ^{[1
]}

机构：

[1] EMORY UNIV,VET ADM MED CTR,SCH MED,DEPT PEDIAT,DECATUR,GA 30033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期

关键词：

D O I：

10.1016/0960-894X(95)00302-A

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of aromatic, water soluble and non-toxic amino acid phosphoramidate di- and triesters of zidovudine (AZT) were shown to inhibit the replication of HIV-1 in human peripheral blood mononuclear cells (PBMC). Cells treated with the active AZT diesters contained four fold more phosphorylated AZT than those treated with AZT, and no free AZT.

引用

页码：1819 / 1824

页数：6

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