DISEASE AND ANATOMIC SPECIFICITY OF ETHANOLAMINE PLASMALOGEN DEFICIENCY IN ALZHEIMERS-DISEASE BRAIN

被引：204

作者：

GINSBERG, L

RAFIQUE, S

XUEREB, JH

RAPOPORT, SI

GERSHFELD, NL

机构：

[1] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,LONDON WC1N 3BG,ENGLAND

[2] UNIV CAMBRIDGE,DEPT PATHOL,CAMBRIDGE,ENGLAND

[3] NIA,NEUROSCI LAB,BETHESDA,MD 20892

[4] NIAMS,PHYS BIOL LAB,BETHESDA,MD

来源：

BRAIN RESEARCH | 1995年 / 698卷 / 1-2期

关键词：

ALZHEIMERS DISEASE; BRAIN; MEMBRANE; LIPID; ETHANOLAMINE PLASMALOGEN;

D O I：

10.1016/0006-8993(95)00931-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A significant and selective deficiency of ethanolamine plasmalogen (PPE) relative to phosphatidylethanolamine was identified in post mortem brain samples from patients with Alzheimer's disease (AD). This lipid defect showed anatomic specificity, being more marked at a site of neurodegeneration in AD brain than in a region relatively spared by the disease (mid-temporal cortex vs. cerebellum) and disease specificity for AD: it was not observed at the primary site of neurodegeneration in Huntington's disease (caudate nucleus) nor Parbinson's disease (substantia nigra). PPE deficiency parallels an inherent tendency towards membrane bilayer instability previously detected in AD brain which is necessarily due to a change in membrane lipid composition, and which may contribute to AD pathogenesis.

引用

页码：223 / 226

页数：4

共 29 条

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