EFFECT OF TRANQUILIZERS ON REGIONAL DISTRIBUTION OF ASCORBIC ACID IN RAT BRAIN

被引：17

作者：

RAJALAKS.R

PATEL, AJ

机构：

[1] Department of Biochemistry, Faculty of Science, M. S. University of Baroda

来源：

JOURNAL OF NEUROCHEMISTRY | 1968年 / 15卷 / 03期

关键词：

D O I：

10.1111/j.1471-4159.1968.tb06195.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

—Studies were made of the effects of fluphenazine, chlorpromazine and triflupromazine on tissue concentration, liver synthesis of ascorbic acid and its distribution in different areas of the brain. All the three drugs were found to increase liver concentration and synthesis of the vitamin at 24 hr after administration of a single oral dose of the vitamin, but only fluphenazine was found to increase its concentration in the adrenals and brain; the increase in the latter case was found to vary in different regions of the brain, the olfactory lobes, hypothalamus and residual brain showing maximum increases, andthe basal ganglia, visual cortex and remaining dorsal cortex showing minimum increases. The effects were found to be reversed 72 hr after drug treatment. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：195 / &

共 12 条

[1]

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[2]

BEYLAND E, 1961, BIOCHEM J, V81, P163

[3]

BURNS JJ, 1960, J PHARMACOL EXP THER, V129, P132

[4]

CHATTERJEE I. B., 1958, SCI AND CULTURE, V23, P382

[5] STIMULATORY EFFECT OF FOREIGN COMPOUNDS ON ASCORBIC ACID BIOSYNTHESIS AND ON DRUG-METABOLIZING ENZYMES [J].