EFFECTS OF CIMETIDINE ON STRESS ULCER AND GASTRIC-ACID SECRETION IN RAT

被引:40
作者
PARE, WP
GLAVIN, GB
VINCENT, GP
机构
[1] Veterans Administration Hospital, Perry Point
关键词
Cimetidine; Gastric acid secretion; Stomach ulcers; Stress; Stress ulcers;
D O I
10.1016/0091-3057(78)90270-8
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Cimetidine at 25, 50, and 100 mg/kg significantly inhibited gastric acid secretion in rats with chronic gastric cannulas. Rats receiving either 50 or 100 mg/kg of cimetidine secreted significantly less gastric acid 3 hr after injection. Cimetidine failed to reduce the number of size of gastric lesions in rats lesions in rats subjected to a supine restraint procedure. © 1978.
引用
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页码:711 / 715
页数:5
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