SOLUTE-SOLVENT INTERACTIONS ON THE SURFACE OF SILICA-GEL .2.

被引:98
作者
SCOTT, RPW
KUCERA, P
机构
[1] Chemical Research Department. Hoffmann-La Roche Inc., Nutley
来源
JOURNAL OF CHROMATOGRAPHY | 1979年 / 171卷 / APR期
关键词
D O I
10.1016/S0021-9673(01)95283-5
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The interactions of solute and solvent on silica gel have been further examined and include adsorption isotherms for non-polar and polar solvents. The formation of a solvent bilayer on the surface of silica gel when using hydrogen-bonding polar solvents is further substantiated, and alternative explanations involving inhomogeneous site activity and steric hindrance are shown not to explain the bilayer formation. It is concluded that when polar-modifying solvents are employed in liquid chromatography at low concentrations, solutes interact with a primary layer of polar solvent wihtout displacing the solvent. At higher concentrations solutes interact with the primary layer, displacing solvents in the second layer, but do not interact directly with the silica gel surface itself. However, for solutes eluted at high K′ values or solutes that have a polarity similar to that of the modifying solvent, competition with the primary layer can take place. Under these circumstances, the solute interacts directly with the silica gel surface. © 1979.
引用
收藏
页码:37 / 48
页数:12
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