HEPATITIS-B VIRUS GENES AND THEIR EXPRESSION IN ESCHERICHIA-COLI

被引：583

作者：

PASEK, M

GOTO, T

GILBERT, W

ZINK, B

SCHALLER, H

MACKAY, P

LEADBETTER, G

MURRAY, K

机构：

[1] UNIV EDINBURGH,SCH MED,DEPT BACTERIOL,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[2] UNIV EDINBURGH,DEPT MOLEC BIOL,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

[3] UNIV HEIDELBERG,DEPT MICROBIOL,D-6900 HEIDELBERG 1,FED REP GER

来源：

NATURE | 1979年 / 282卷 / 5739期

关键词：

D O I：

10.1038/282575a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A composite DNA sequence of regions of hepatitis B virus, determined from a series of recombinant plasmids, reveals the genes for the surface antigen and the core antigen of the virus. The sequence of the core antigen shows it to be a DNA binding protein. The core antigen gene is expressed in Escherichia coli and when injected into rabbits the bacterial product induces antibodies which react with core antigen isolated from human sources. © 1979 Nature Publishing Group.

引用

页码：575 / 579

页数：5

共 24 条

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