COMBINED CHEMOENZYMATIC SYNTHESIS OF N-GLYCOPROTEIN BUILDING-BLOCKS

被引：67

作者：

THIEM, J

WIEMANN, T

机构：

[1] Organisch‐chemisches Institut, Universität Münster, D‐4400

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 01期

关键词：

D O I：

10.1002/anie.199000801

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Partial structures of N‐glycoproteins that are of decisive importance for biological recognition processes on the cellular and molecular level can be prepared by a combination of chemical and enzymatic steps. The aspartyl‐glucosaminyl unit is first synthesized chemically; the subsequent galactosylation to 1 is achieved enzymatically in the presence of galactosyltransferase. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

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页码：80 / 82

页数：3

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