A PHARMACOLOGICAL EVALUATION OF BAPHIA-NITIDA LODD (LEGUMINOSAE) ETHANOLIC EXTRACT ON RATS AND MICE

被引：6

作者：

ONWUKAEME, DN ^{[1
]}

LOT, TY ^{[1
]}

机构：

[1] UNIV JOS,FAC PHARMACEUT SCI,DEPT CLIN PHARM,JOS,NIGERIA

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 06期

关键词：

PHYTOCHEMICAL; PHARMACOLOGICAL EXAMINATION; BAPHIA-NITIDA EXTRACT; RATS; MICE;

D O I：

10.1002/ptr.2650050605

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fresh leaves of Baphia nitida supplied by a herbalist were extracted, screened phytochemically and then subjected to various pharmacological tests. The phytochemical tests showed the presence of saponin, flavonoid glycosides and true tannins. In the dose range used, no acute toxicity was observed for the ethanolic extract. The extract showed a dose dependent antinociceptive (analgesic) activity in mice with the analgesic activity of 500 mg/kg extract being comparable to that of 300 mg/kg of acetylsalicylic acid. The extract demonstrated an antidiarrhoeal effect by protecting rats against castor oil induced diarrhoea. This was also dose related but less than the protection afforded by sodium salicylate. The extract did not demonstrate any appreciable anticonvulsant effect against strychnine-induced convulsion in rats.

引用

页码：254 / 257

页数：4

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