TIME COURSE OF CARDIAC SYMPATHETIC AND VAGAL TONE CHANGES IN RENOVASCULAR HYPERTENSIVE RATS

被引：17

作者：

CABRAL, AM ^{[1
]}

VASQUEZ, EC ^{[1
]}

机构：

[1] UNIV FED ESPIRITO SANTO,CTR BIOMED,DEPT CIENCIAS FISIOL,CP 780,BR-29001 VITORIA,ES,BRAZIL

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 10期

关键词：

RENOVASCULAR HYPERTENSION; HEART RATE; ARTERIAL PRESSURE; SYMPATHETIC TONE; VAGAL TONE;

D O I：

10.1093/ajh/4.10.815

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The present study has examined the time course of autonomic tone changes in two-kidney, one-clip (2K1C) and one-kidney, one-clip (1K1C) renal hypertension. In conscious rats, cardiac sympathetic and vagal tone were determined using propranolol and atropine, respectively. The development of renovascular hypertension was accompanied by a significant tachycardia, increase in cardiac sympathetic tone and decrease in cardiac vagal tone. In the isolated perfused heart we observed a reduced chronotropic response to isoproterenol. These alterations were transitory in 2K1C and greater and more persistent in 1K1C renal hypertension. These results show the relative role played by the cardiac sympathetic and vagal systems in the maintenance of tachycardia in renovascular hypertension.

引用

页码：815 / 819

页数：5

共 10 条

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