MOLECULAR MECHANISM OF INHIBITION OF MAMMALIAN PROTEIN-SYNTHESIS BY SOME 4-CHAIN AGGLUTININS - PROPOSAL OF AN EXTENDED CLASSIFICATION OF PLANT RIBOSOME-INACTIVATING PROTEINS (RIBOSOMAL-RNA N-GLYCOSIDASES)

被引：42

作者：

CITORES, L ^{[1
]}

FERRERAS, JM ^{[1
]}

IGLESIAS, R ^{[1
]}

CARBAJALES, ML ^{[1
]}

ARIAS, FJ ^{[1
]}

JIMENEZ, P ^{[1
]}

ROJO, MA ^{[1
]}

GIRBES, T ^{[1
]}

机构：

[1] UNIV VALLADOLID,FAC CIENCIAS,DEPT BIOQUIM & BIOL MOLEC,E-47005 VALLADOLID,SPAIN

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

RIBOSOME-INACTIVATING PROTEIN; PROTEIN SYNTHESIS; INHIBITION; 4-CHAIN AGGLUTININ; RIBOSOMAL-RNA N-GLYCOSIDASE;

D O I：

10.1016/0014-5793(93)80193-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The four chain agglutinins from Abrus precatorius, Viscum album and Ricinus communis promote depurination of the 28 S rRNA from rabbit reticulocyte ribosomes characteristic of the common ribosome-inactivating proteins (RIPs). These agglutinins inhibited mammalian protein synthesis at nanomolar concentrations but they do not affect plant protein synthesis under the same conditions. Therefore, they should also be considered as true RIPs but of a new class, the four-chain RIPs. An extended classification of RIPs is presented based on the former one from Stirpe et al. [Bio/technology 10 (1992) 405-412].

引用

页码：59 / 62

页数：4

共 21 条

[1]

ARIAS FJ, 1992, PLANTA, V186, P532, DOI 10.1007/BF00198033

[2] PREPARATION AND OPTIMIZATION OF A CELL-FREE TRANSLATION SYSTEM FROM VICIA-SATIVA GERM LACKING RIBOSOME-INACTIVATING PROTEIN-ACTIVITY [J].