RESUSCITATION FROM BUPIVACAINE-INDUCED ASYSTOLE IN RATS - COMPARISON OF DIFFERENT CARDIOACTIVE DRUGS

被引:29
作者
HEAVNER, JE [1 ]
PITKANEN, MT [1 ]
SHI, B [1 ]
ROSENBERG, PH [1 ]
机构
[1] TOOLO HOSP,HELSINKI,FINLAND
关键词
D O I
10.1097/00000539-199506000-00011
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The objective of this study was to compare the success of resuscitation attempts with different cardioactive drugs after bupivacaine-induced asystole. Saline, amrinone (1 mg/kg), dopamine (5 (mu g/kg), norepinephrine (2 mu g/kg), epinephrine (10 mu g/kg), or isoproterenol (1 mu g/kg) were tested. Sixty rats assigned to six treatment groups (n = 10/group) were Lightly anesthetized (0.5% halothane, 70% N2O), paralyzed (doxacurium), and given bupivacaine intravenously at 4 mg . kg(-1). min(-1) until asystole. Five seconds later up to three treatment drug doses were given at 30-s intervals. Then external cardiac massage was instituted as needed. Spontaneous heartbeat was restored in all animals given norepinephrine or epinephrine. It was not restored in one saline-one dopamine-treated, one isoproterenol-treated and three amrinone-treated animals. The highest (best) arbitrary scores for overall resuscitation success were achieved with norepinephrine and the lowest with amrinone (P < 0.05). The incidence of ventricular arrhythmias after resuscitation was significantly higher (P < 0.05) in epinephrine- and isoproterenol-treated animals versus other animals. Cardiac rhythm disturbance disappeared within 20 min after successful resuscitation with norepinephrine. Amrinone was no more effective than saline in treating bupivacaine-induced asystole. A drug such as norepinephrine, which has both cardiostimulator (beta(1)-receptor agonist) and peripheral vasoconstrictor (alpha(1)-receptor agonist) activity, may be the drug of choice for treating asystole induced by bupivacaine.
引用
收藏
页码:1134 / 1139
页数:6
相关论文
共 15 条
[1]   CARDIAC-ARREST FOLLOWING REGIONAL ANESTHESIA WITH ETIDOCAINE OR BUPIVACAINE [J].
ALBRIGHT, GA .
ANESTHESIOLOGY, 1979, 51 (04) :285-287
[2]   TOXICITY AND RESUSCITATION IN LIDOCAINE-INFUSED OR BUPIVACAINE-INFUSED CATS [J].
CHADWICK, HS .
ANESTHESIOLOGY, 1985, 63 (04) :385-390
[3]  
COYLE DE, 1994, ANESTH ANALG, V79, P335
[4]  
FELDMAN HS, 1991, ANESTH ANALG, V73, P373
[5]  
FELDMAN HS, 1989, ANESTH ANALG, V69, P794
[6]  
HA HR, 1984, ANESTH ANALG, V63, P448
[7]  
Hoffmann BB, 1990, PHARMACOL BASIS THER, P187
[8]  
KASTEN GW, 1986, ANESTH ANALG, V65, P1029
[9]  
LACOMBE P, 1991, ANESTH ANALG, V72, P70
[10]  
LACOUSSAYE JE, 1991, REGION ANESTH, V16, P120