ENHANCED DETECTION OF ANTIBODIES TO HEPATITIS-C VIRUS BY USE OF A 3RD-GENERATION RECOMBINANT IMMUNOBLOT ASSAY

被引：27

作者：

BUFFET, C ^{[1
]}

CHARNAUX, N ^{[1
]}

LAURENTPUIG, P ^{[1
]}

CHOPINEAU, S ^{[1
]}

QUICHON, JP ^{[1
]}

BRIANTAIS, MJ ^{[1
]}

DUSSAIX, E ^{[1
]}

机构：

[1] HOP BICETRE,VIROL LAB,F-94270 LE KREMLIN BICETR,FRANCE

来源：

JOURNAL OF MEDICAL VIROLOGY | 1994年 / 43卷 / 03期

关键词：

HCV; RIBA; PCR;

D O I：

10.1002/jmv.1890430312

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fifty-seven sera with indeterminate results by the second generation RIBA (RIBA 2) for confirmation of hepatitis C virus (HCV) enzyme linked immunoassay (ELISA) reactivity were tested by the new third generation RIBA (RIBA 3). Thirty three (57.9%) displayed reactivity for at least one other band and were therefore classified as positive; two became negative and 22 (38%) remained indeterminate. The incidence of HCV viremia, as determined by the RNA polymerase chain reaction (PCR), was 75% for the latter sera. The data show that it is important to subject RIBA 3 indeterminate samples to PCR. (C) 1994 Wiley-Liss, Inc.

引用

页码：259 / 261

页数：3

共 6 条

[1] HEPATITIS-C VIRUS-INFECTION IN PEDIATRIC LIVER-TRANSPLANTATION [J].

DUSSAIX, E ;

DEPAILLETTE, L ;

LAURENTPUIG, P ;

MARTRES, P ;

LYKAVIERIS, P ;

BERNARD, O ;

ALVAREZ, F .

TRANSPLANTATION, 1993, 55 (04) :795-798

[2]

HALPHON P, 1992, J INFECT DIS, V166, P449

[3] IMPROVED DETECTION OF ANTIBODIES TO HEPATITIS-C VIRUS BY USE OF A NEW RECOMBINANT IMMUNOBLOT ASSAY [J].

JOLLERJEMELKA, HI ;

WICKI, AN ;

OPITZ, R .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1993, 12 (05) :398-400

[4] INDETERMINATE HEPATITIS-C [J].

LI, XM ;

REDDY, KR ;

JEFFERS, LJ ;

PARKER, T ;

DEMEDINA, M ;

SCHIFF, ER .

LANCET, 1993, 341 (8848) :835-835

[5]

MACEDO G, 1993, GASTROENTEROLOGY, V104, pA947

[6] CONFIRMATION OF HEPATITIS-C VIRUS-INFECTION BY NEW 4-ANTIGEN RECOMBINANT IMMUNOBLOT ASSAY [J].

VANDERPOEL, CL ;

CUYPERS, HTM ;

REESINK, HW ;

WEINER, AJ ;

QUAN, S ;

DINELLO, R ;

VANBOVEN, JJP ;

WINKEL, I ;

MULDERFOLKERTS, D ;

EXELOEHLERS, PJ ;

SCHAASBERG, W ;

LEENTVAARKUYPERS, A ;

POLITO, A ;

HOUGHTON, M ;

LELIE, PN .

LANCET, 1991, 337 (8737) :317-319

← 1 →