NA(+),K(+)-ATPASE OF GASTRIC CELLS - A TARGET OF HELICOBACTER-PYLORI CYTOTOXIC ACTIVITY

被引：22

作者：

RICCI, V

SOMMI, P

COVA, E

FIOCCA, R

ROMANO, M

IVEY, KJ

SOLCIA, E

VENTURA, U

机构：

[1] UNIV PAVIA,INST HUMAN PHYSIOL,I-27100 PAVIA,ITALY

[2] UNIV PAVIA,DEPT HUMAN PATHOL,I-27100 PAVIA,ITALY

[3] UNIV NAPLES,DEPT MED,I-80131 NAPLES,ITALY

[4] VAMC,DEPT MED,LONG BEACH,CA 90822

来源：

FEBS LETTERS | 1993年 / 334卷 / 02期

关键词：

NA+; K+-ATPASE; HELICOBACTER-PYLORI; CYTOTOXICITY; CELL VACUOLATION; K+-DEPENDENT PHOSPHATASE ACTIVITY; CULTURED GASTRIC CELLS;

D O I：

10.1016/0014-5793(93)81703-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study shows a direct impairing action of a cytotoxin-producing Helicobacter pylori strain on the Na+,K+-ATPase (evaluated as K+-dependent phosphatase activity) of human gastric epithelial cells in culture. The toxin itself is likely involved in this action which may also account for the cell edema found in vivo in Helicobacter pylori-colonized stomach.

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收藏

页码：158 / 160

页数：3

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