PLASTICITY OF COMPLEX TERMINALS IN LAMINA-II IN PARTIALLY DEAFFERENTED SPINAL-CORD - THE CAT SPARED ROOT PREPARATION

被引:22
作者
ZHANG, B
GOLDBERGER, ME
WU, LF
MURRAY, M
机构
[1] MED COLL PENN,DEPT ANAT & NEUROBIOL,PHILADELPHIA,PA 19129
[2] W CHINA UNIV MED SCI,DEPT HISTOL & EMBRYOL,CHENGDU,PEOPLES R CHINA
关键词
D O I
10.1016/0014-4886(95)90024-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Projections to the dorsal horn change in adult mammals in response to complete or partial deafferentation. The number of synaptic terminals remains constant after complete lumbosacral deafferentation, indicating replacement of lost dorsal root terminals by newly formed terminals from spared intrinsic systems. The density of a spared central projection of a dorsal root is increased in dorsal horn after partial deafferentation, consistent with sprouting by the axons in the spared root. In this study, we have used electron microscopy to study morphological changes in a specific class of terminals in the dorsal horn induced by partial deafferentation. Complex terminals (CTs) in the dorsal horn originate exclusively from dorsal roots and are readily distinguished morphologically. The CTs and the postsynaptic densities (PSDs) associated with CTs were measured in lamina II at L5 and L6 in cats subjected to unilateral spared root (L6) dorsal rhizotomies and compared to CTs in the control side. Acutely following partial deafferentation, the number of CT profiles decreased. At more chronic survivals, the number of CT profiles were restored to normal levels, and both the number and the length of PSDs were increased. The changes in CTs and PSDs suggest sprouting and synaptogenesis by the spared dorsal root fibers that produce changes in the postsynaptic neuron. Spared root deafferentation thus elicits compensatory changes in presynaptic terminals of the spared root and also in their postsynaptic target neurons. (C) 1995 Academic Press, Inc.
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页码:186 / 193
页数:8
相关论文
共 54 条
[1]   FUNCTION OF CALMODULIN IN POSTSYNAPTIC DENSITIES .3. CALMODULIN-BINDING PROTEINS OF THE POSTSYNAPTIC DENSITY [J].
CARLIN, RK ;
GRAB, DJ ;
SIEKEVITZ, P .
JOURNAL OF CELL BIOLOGY, 1981, 89 (03) :449-455
[2]   IDENTIFICATION OF FODRIN AS A MAJOR CALMODULIN-BINDING PROTEIN IN POSTSYNAPTIC DENSITY PREPARATIONS [J].
CARLIN, RK ;
BARTELT, DC ;
SIEKEVITZ, P .
JOURNAL OF CELL BIOLOGY, 1983, 96 (02) :443-447
[3]   THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN [J].
CHO, KO ;
HUNT, CA ;
KENNEDY, MB .
NEURON, 1992, 9 (05) :929-942
[4]   SUBSTANTIA GELATINOSA ROLANDI OF RAT - FINE-STRUCTURE, CYTOCHEMISTRY (ACID-PHOSPHATASE) AND CHANGES AFTER DORSAL ROOT SECTION [J].
COIMBRA, A ;
SODREBOR.BP ;
MAGALHAES, MM .
JOURNAL OF NEUROCYTOLOGY, 1974, 3 (02) :199-217
[5]  
DESMOND N L, 1984, Society for Neuroscience Abstracts, V10, P77
[6]   INDUCTION OF LONG-TERM POTENTIATION IS ASSOCIATED WITH AN INCREASE IN THE NUMBER OF AXOSPINOUS SYNAPSES WITH SEGMENTED POSTSYNAPTIC DENSITIES [J].
GEINISMAN, Y ;
DETOLEDOMORRELL, L ;
MORRELL, F .
BRAIN RESEARCH, 1991, 566 (1-2) :77-88
[7]   THE BRAINS RECORD OF EXPERIENCE - KINDLING-INDUCED ENLARGEMENT OF THE ACTIVE ZONE IN HIPPOCAMPAL PERFORATED SYNAPSES [J].
GEINISMAN, Y ;
DETOLEDOMORRELL, L ;
MORRELL, F .
BRAIN RESEARCH, 1990, 513 (01) :175-179
[8]   INCREASE IN THE RELATIVE PROPORTION OF PERFORATED AXOSPINOUS SYNAPSES FOLLOWING HIPPOCAMPAL KINDLING IS SPECIFIC FOR THE SYNAPTIC FIELD OF STIMULATED AXONS [J].
GEINISMAN, Y ;
MORRELL, F ;
DETOLEDOMORRELL, L .
BRAIN RESEARCH, 1990, 507 (02) :325-331
[9]   INCREASE IN THE NUMBER OF AXOSPINOUS SYNAPSES WITH SEGMENTED POSTSYNAPTIC DENSITIES FOLLOWING HIPPOCAMPAL KINDLING [J].
GEINISMAN, Y ;
MORRELL, F ;
DETOLEDOMORRELL, L .
BRAIN RESEARCH, 1992, 569 (02) :341-347
[10]   RESTITUTION OF FUNCTION AND COLLATERAL SPROUTING IN CAT SPINAL-CORD - DEAFFERENTED ANIMAL [J].
GOLDBERGER, ME ;
MURRAY, M .
JOURNAL OF COMPARATIVE NEUROLOGY, 1974, 158 (01) :37-54