HORMONAL INDUCTION OF INCREASED ZINC UPTAKE IN MAMMALIAN CELL CULTURES - REQUIREMENT FOR RNA AND PROTEIN SYNTHESIS

被引：22

作者：

COX, RP

机构：

[1] Department of Medicine, New York University School of Medicine, New York

来源：

SCIENCE | 1969年 / 165卷 / 3889期

关键词：

D O I：

10.1126/science.165.3889.196

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The zinc content of HeLa S3 cells is markedly increased after growth in medium containing adrenal glucocorticoid hormones. Studies with inhibitors indicate that the synthesis of RNA and protein is required for enhanced zinc uptake. When protein synthesis is blocked in the presence of the steroid, an intermediate, presumably messenger RNA, which specifies enhanced zinc uptake accumulates and is expressed when the inhibition of protein synthesis is removed.

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页码：196 / +

页数：1

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