CENTRALLY ACTING EMETICS .3. DERIVATIVES OF BETA-NAPHTHYLAMINE

被引：24

作者：

SPRENGER, WK

CANNON, JG

BARMAN, BK

机构：

[1] Division of Medicinal Chemistry, College of Pharmacy, University of Iowa, Iowa City

[2] Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a602

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of β-naphthylamine derivatives closely corresponding to a portion of the apomorphine molecule was undertaken to investigate structure-activity relationships of this centrally active emetic. Employing independent synthetic routes, derivatives of 2-amino-5,6-naphthalenediol and of 2-amino-1,2,3,4-tetrahydronaphthalene-5,6-diol have been prepared. Biological test data are presented. © 1969, American Chemical Society. All rights reserved.

引用

页码：487 / &

共 11 条

[1] BERGELL P, 1904, THER GEGENW, V45, P247
[2] SYNTHESIS OF 8-ISOPROPYLPODOCARPANE-6,7-DIOL (6-HYDROXYTOTAROL) AND OF 7,8-DIMETHOXYPODOCARPANE
ELMORE, NF
KING, TJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1961, (OCT): : 4425 - &
[3] THE SYNTHESIS OF RING SYSTEMS RELATED TO MORPHINE .3. 5,6-DIMETHOXY-4-CYANOMETHYL-1,2-NAPHTHOQUINONE AND ITS CONDENSATION WITH DIENES
GATES, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (01) : 228 - 234
[4] Hartung W.H., 1943, ORG SYNTH, VII, P363
[5] *UBER DIE METHYLIERUNG VON AROMATISCHEN AMINEN MIT DIMETHYLSULFAT
HUNIG, S
[J]. CHEMISCHE BERICHTE-RECUEIL, 1952, 85 (11): : 1056 - 1060
[6] CENTRALLY ACTING EMETICS .2. NORAPOMORPHINE AND DERIVATIVES
KOCH, MV
CANNON, JG
BURKMAN, AM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (05) : 977 - &
[7] REARRANGEMENT OF KETOXIME O-SULFONATES TO AMINO KETONES
OBRIEN, C
[J]. CHEMICAL REVIEWS, 1964, 64 (02) : 81 - &
[8] Small LF, 1938, PUBLIC HLTH REPORT S, V138, P1
[9] STRAUS F, 1925, ANN, V444, P146
[10] DERIVATIVES OF 2-AMINOTETRALIN
THRIFT, RI
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (04): : 288 - &

← 1 2 →