HPLC METHOD FOR THE DETERMINATION OF CHLOROQUINE AND ITS MAIN METABOLITE IN BIOLOGICAL SAMPLES

被引：20

作者：

AUGUSTIJNS, P

VERBEKE, N

机构：

[1] Klinische Farmacie Laboratorium voor Galenische en Klinische Farmacie, O & N Gasthuisberg, 3000, Leuven

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 06期

关键词：

D O I：

10.1080/01483919008049243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An ion-pair reversed phase HPLC-method for the determination of chloroquine and desethylchloroquine in plasma, blood and filter-paper-absorbed blood spots is described. Using 75 (μ1samples, concentrations ranging from 2 to 1000 ng/ml can be measured. Intraday precision as well as interday precision are lower than 6 % (RSD). The filter-paper method could be used for the determination of chloroquine and desethylchloroquine in samples originating from areas with a lack of laboratory equipment. The procedure is sensitive enough to be used in monitoring of drug levels as well as for pharmacokinetic studies. © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：1203 / 1213

页数：11

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