EFFICACY OF ACC-9653 (A PHENYTOIN PRODRUG) IN EXPERIMENTAL STATUS EPILEPTICUS IN THE RAT

被引：20

作者：

WALTON, NY

TREIMAN, DM

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024

[2] VET ADM MED CTR,NEUROL SERV,LOS ANGELES,CA

[3] VET ADM MED CTR,RES SERV,LOS ANGELES,CA

来源：

EPILEPSY RESEARCH | 1990年 / 5卷 / 02期

关键词：

(Rats); ACC-9653; Phenytoin; Phenytoin prodrug; Status epilepticus; Treatment;

D O I：

10.1016/0920-1211(90)90034-S

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Status epilepticus was induced by injection of homocysteine thiolactone to rats with epileptogenic cortical cobalt lesions. Either standard phenytoin or ACC-9653 (a phenytoin prodrug) was injected after the second generalized tonic-clonic seizure. Rats treated with ACC-9653 had significantly poorer treatment outcomes than rats treated with standard phenytoin, although no differences were found in the concentration of phenytoin in plasma or brain 65 min after injection. © 1990.

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页码：165 / 168

页数：4

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