SYNTHESIS AND PHARMACOLOGY OF A SERIES OF 3-(PHOSPHONOALKYL)PYRIDINE-2-CARBOXYLIC AND 4-(PHOSPHONOALKYL)PYRIDINE-2-CARBOXYLIC AND 4-(PHOSPHONOALKYL)PIPERIDINE-2-CARBOXYLIC ACIDS - POTENT N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS

被引：68

作者：

ORNSTEIN, PL

SCHAUS, JM

CHAMBERS, JW

HUSER, DL

LEANDER, JD

WONG, DT

PASCHAL, JW

JONES, ND

DEETER, JB

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 04期

关键词：

D O I：

10.1021/jm00124a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：827 / 833

页数：7

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共 39 条

[1] Esters of pyridinecarboxylic acids as local anesthetics
Blicke, FF
Jenner, EL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1942, 64 : 1721 - 1724
[2] ANTICONVULSANT ACTION AND BIOCHEMICAL EFFECTS IN DBA 2 MICE OF CPP (3-((+/-)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONATE), A NOVEL N-METHYL-D-ASPARTATE ANTAGONIST
CHAPMAN, AG
MELDRUM, BS
NANJI, N
WATKINS, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 139 (01) : 91 - 96
[3] ANTICONVULSANT ACTION OF EXCITATORY AMINO-ACID ANTAGONISTS
CROUCHER, MJ
COLLINS, JF
MELDRUM, BS
[J]. SCIENCE, 1982, 216 (4548) : 899 - 901
[4] ANTAGONISM OF N-METHYL-D,L-ASPARTIC ACID-INDUCED CONVULSIONS BY ANTIEPILEPTIC DRUGS AND OTHER AGENTS
CZUCZWAR, SJ
FREY, HH
LOSCHER, W
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 108 (03) : 273 - 280
[5] PROTECTION AGAINST CHEMICALLY-INDUCED SEIZURES BY 2-AMINO-7-PHOSPHONOHEPTANOIC ACID
CZUCZWAR, SJ
MELDRUM, B
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 83 (3-4) : 335 - 338
[6] DIFFERENTIAL ACTIVATION AND BLOCKADE OF EXCITATORY AMINO-ACID RECEPTORS IN THE MAMMALIAN AND AMPHIBIAN CENTRAL NERVOUS SYSTEMS
DAVIES, J
EVANS, RH
JONES, AW
SMITH, DAS
WATKINS, JC
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1982, 72 (02): : 211 - 224
[7] CPP, A NEW POTENT AND SELECTIVE NMDA ANTAGONIST - DEPRESSION OF CENTRAL NEURON RESPONSES, AFFINITY FOR [H-3] D-AP5 BINDING-SITES ON BRAIN MEMBRANES AND ANTICONVULSANT ACTIVITY
DAVIES, J
EVANS, RH
HERRLING, PL
JONES, AW
OLVERMAN, HJ
POOK, P
WATKINS, JC
[J]. BRAIN RESEARCH, 1986, 382 (01) : 169 - 173
[8] DAVIES J, 1983, EXCITOTOXINS, P43
[9] PHARMACOLOGICAL ANTAGONISTS OF EXCITANT AMINO-ACID ACTION
EVANS, RH
WATKINS, JC
[J]. LIFE SCIENCES, 1981, 28 (12) : 1303 - 1308
[10] THE EFFECTS OF A SERIES OF OMEGA-PHOSPHONIC ALPHA-CARBOXYLIC AMINO-ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID-INDUCED RESPONSES IN ISOLATED SPINAL-CORD PREPARATIONS
EVANS, RH
FRANCIS, AA
JONES, AW
SMITH, DAS
WATKINS, JC
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1982, 75 (01) : 65 - 75

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