INTRATHECAL CAPSAICIN DEPLETES SUBSTANCE-P IN THE RAT SPINAL-CORD AND PRODUCES PROLONGED THERMAL ANALGESIA

被引：290

作者：

YAKSH, TL

FARB, DH

LEEMAN, SE

JESSELL, TM

机构：

[1] HARVARD UNIV, SCH MED, DEPT PHYSIOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PHARMACOL, BOSTON, MA 02115 USA

来源：

SCIENCE | 1979年 / 206卷 / 4417期

关键词：

D O I：

10.1126/science.228392

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli. Copyright © 1979 AAAS.

引用

页码：481 / 483

页数：3

共 25 条

[1] ORIGIN, DISTRIBUTION AND SYNAPTIC RELATIONSHIPS OF SUBSTANCE-P AXONS IN RAT SPINAL-CORD
BARBER, RP
VAUGHN, JE
SLEMMON, JR
SALVATERRA, PM
ROBERTS, E
LEEMAN, SE
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1979, 184 (02) : 331 - 351
[2] EFFECTS OF CENTRAL LESIONS ON DISORDERS PRODUCED BY MULTIPLE DORSAL RHIZOTOMY IN RATS
BASBAUM, AI
[J]. EXPERIMENTAL NEUROLOGY, 1974, 42 (03) : 490 - 501
[3] ULTRASTRUCTURAL IDENTIFICATION OF SUBSTANCE P-CELLS AND THEIR PROCESSES IN RAT SENSORY GANGLIA AND THEIR TERMINALS IN SPINAL-CORD BY IMMUNOCYTOCHEMISTRY - (GRANULES-STORAGE-RELEASE-EXTRACELLULAR-SYNAPTIC)
CHANPALAY, V
PALAY, SL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) : 4050 - 4054
[4] SEROTONIN AND SUBSTANCE-P COEXIST IN NEURONS OF RATS CENTRAL NERVOUS-SYSTEM
CHANPALAY, V
JONSSON, G
PALAY, SL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (03) : 1582 - 1586
[5] SUBSTANCE-P - LOCALIZATION IN SYNAPTIC VESICLES IN RAT CENTRAL NERVOUS-SYSTEM
CUELLO, AC
JESSELL, TM
KANAZAWA, I
IVERSEN, LL
[J]. JOURNAL OF NEUROCHEMISTRY, 1977, 29 (04) : 747 - +
[6] GASPAROVIC I, 1964, MED EXP, V10, P303
[7] EFFECTS OF SUBSTANCE-P ON FUNCTIONALLY IDENTIFIED UNITS IN CAT SPINAL-CORD
HENRY, JL
[J]. BRAIN RESEARCH, 1976, 114 (03) : 439 - 451
[8] IMMUNOHISTOCHEMICAL EVIDENCE OF SUBSTANCE P-LIKE IMMUNOREACTIVITY IN SOME 5-HYDROXYTRYPTAMINE-CONTAINING NEURONS IN RAT CENTRAL NERVOUS-SYSTEM
HOKFELT, T
LJUNGDAHL, A
STEINBUSCH, H
VERHOFSTAD, A
NILSSON, G
BRODIN, E
PERNOW, B
GOLDSTEIN, M
[J]. NEUROSCIENCE, 1978, 3 (06) : 517 - +
[9] EXPERIMENTAL IMMUNOHISTOCHEMICAL STUDIES ON LOCALIZATION AND DISTRIBUTION OF SUBSTANCE-P IN CAT PRIMARY SENSORY NEURONS
HOKFELT, T
KELLERTH, JO
NILSSON, G
PERNOW, B
[J]. BRAIN RESEARCH, 1975, 100 (02) : 235 - 252
[10] IMMUNOHISTOCHEMICAL ANALYSIS OF PEPTIDE PATHWAYS POSSIBLY RELATED TO PAIN AND ANALGESIA - ENKEPHALIN AND SUBSTANCE-P
HOKFELT, T
LJUNGDAHL, A
TERENIUS, L
ELDE, R
NILSSON, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) : 3081 - 3085

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