DEVELOPMENT OF MONOAMINERGIC NEUROTRANSMITTERS IN FETAL AND POSTNATAL RAT-BRAIN - ANALYSIS BY HPLC WITH ELECTROCHEMICAL DETECTION

被引：51

作者：

HERREGODTS, P

VELKENIERS, B

EBINGER, G

MICHOTTE, Y

VANHAELST, L

HOOGHEPETERS, E

机构：

[1] VRIJE UNIV BRUSSELS,DEPT PHARMACOL,B-1050 BRUSSELS,BELGIUM

[2] UNIV HOSP BRUSSELS,DEPT PHARMACEUT CHEM & DRUG ANAL,BRUSSELS,BELGIUM

[3] UNIV HOSP BRUSSELS,DEPT NEUROL,BRUSSELS,BELGIUM

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 03期

关键词：

Catecholamines; Development; Electrochemical detection; High performance liquid chromatography; Rat brain; Serotonin;

D O I：

10.1111/j.1471-4159.1990.tb04559.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: The monoamines dopamine, norepinephrine, epinephrine, and serotonin and their major metabolites 3,4‐dihydroxyphenylacetic acid, homovanillic acid, 3‐methoxy‐4‐hydroxyphenylethylene glycol, and 5‐hydroxyindoleacetic acid were measured in the CNS of the rat during development from fetal day 18 to young adult. The catecholamines, serotonin, and their major metabolites remained low during fetal life. Concentrations measured in total brain started to increase around birth till the end of the fourth week of life after which steady‐state levels were measured. Our results suggest that although monoamine systems are already morphologically well developed during late gestational life, they probably become a significant functional system only around birth and early postnatal life. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：774 / 779

页数：6

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