POLIOVIRUS CHIMERAS EXPRESSING SEQUENCES FROM THE PRINCIPAL NEUTRALIZATION DOMAIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引:51
作者
DEDIEU, JF
RONCO, J
VANDERWERF, S
HOGLE, JM
HENIN, Y
GIRARD, M
机构
[1] INST PASTEUR, UNITE VIROL MOLEC, CNRS, UA 545, 25 RUE DR ROUX, F-75724 PARIS 15, FRANCE
[2] INST PASTEUR, UNITE ONCOL VIRALE, F-75724 PARIS, FRANCE
[3] PASTEUR MERIEUX SERUMS & VACCINS, F-27101 VAL DE REUIL, FRANCE
[4] Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA
关键词
D O I
10.1128/JVI.66.5.3161-3167.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sequences from the principal neutralization domain of human immunodeficiency virus type 1 (HIV-1) strain LAI or RF have been expressed in antigenic site 1 of the capsid of the Sabin strain of poliovirus type 1. A number of the resulting chimeras were viable. Viable variants bearing mutations within the insertion site spontaneously arose from several nonviable chimeras. In general, these mutations result in a decrease in positive charge in the substituted antigenic site 1. Two of the chimeras were genetically stable and have been further characterized. Both chimeras were neutralized by various HIV-1 neutralizing antibodies. In rabbits, both chimeras produced high levels of antibodies which react with HIV-1 gp120/160 in immunoprecipitation and enzyme-linked immunosorbent assays. One of the chimeras (HIV-1LAI) produced a significant but weak HIV-1 neutralizing response.
引用
收藏
页码:3161 / 3167
页数:7
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