STEREOCONTROLLED SYNTHESIS OF SIALYL LEX, THE OLIGOSACCHARIDE BINDING LIGAND TO ELAM-1 (SIALYL = N-ACETYLNEURAMIN)

被引：134

作者：

NICOLAOU, KC ^{[1
]}

HUMMEL, CW ^{[1
]}

BOCKOVICH, NJ ^{[1
]}

WONG, CH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT CHEM, LA JOLLA, CA 92093 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 13期

关键词：

D O I：

10.1039/c39910000870

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sialyl Le(x) 1 the oligosaccharide binding ligand to ELAM-1 is synthesized from building blocks 2-5 via a short route featuring the principle of a neighbouring PhS group as an auxiliary to facilitate and stereochemically control the formation of the desired glycoside bond in the target molecule.

引用

页码：870 / 872

页数：3

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