STRAIN-DEPENDENT DIFFERENCES IN RESPONSIVENESS OF MICE TO NITROUS-OXIDE (N2O) ANTINOCICEPTION

被引：22

作者：

QUOCK, RM ^{[1
]}

MUELLER, JL ^{[1
]}

VAUGHN, LK ^{[1
]}

机构：

[1] MARQUETTE UNIV, SCH DENT, DEPT BASIC SCI, MILWAUKEE, WI 53233 USA

来源：

BRAIN RESEARCH | 1993年 / 614卷 / 1-2期

关键词：

N2O; ANTINOCICEPTION; OPIOID SYSTEM; INBRED AND OUTBRED MOUSE STRAINS;

D O I：

10.1016/0006-8993(93)91017-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

N2O antinociception was assessed in eight inbred and two outbred mouse strains. Results indicated the following order of responsiveness among the 10 strains: A/J (most sensitive), C57BL/6ByJ, C57BL/6J, BALB/cByJ, C3H/HeJ, Swiss-Webster, CXBK/ByJ, ICR, CBA/J and DBA/2J (least sensitive). These results demonstrate significant strain-dependent differences in antinociceptive responsiveness to N2O. The weak antinociceptive response to N2O in the DBA/2J strain, which is sensitive to morphine and U-50,488H, indicates some underlying neurobiological difference in the DBA/2J mouse that imparts resistance to N2O. The responsiveness of CXBK/ByJ mice to N2O indicates that mu-opioid receptors may not play an important role in N2O antinociception in mice.

引用

页码：52 / 56

页数：5

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