STRUCTURE OF A PLASMODIUM-CHABAUDI ACIDIC PHOSPHOPROTEIN THAT IS ASSOCIATED WITH THE HOST ERYTHROCYTE-MEMBRANE

被引：8

作者：

DELEERSNIJDER, W ^{[1
]}

PRASOMSITTI, P ^{[1
]}

TUNGPRADUBKUL, S ^{[1
]}

HENDRIX, D ^{[1
]}

HAMERSCASTERMAN, C ^{[1
]}

HAMERS, R ^{[1
]}

机构：

[1] VRIJE UNIV BRUSSELS,INST MOLEC BIOL,ALGEMENE BIOL LAB,PAARDENSTR 65,1640 ST GENESIUS RODE,B-1050 BRUSSELS,BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1992年 / 56卷 / 01期

关键词：

MALARIA; PLASMODIUM-CHABAUDI; ERYTHROCYTE CYTOSKELETON; TANDEM REPEATS; PHOSPHOPROTEIN;

D O I：

10.1016/0166-6851(92)90154-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have characterized by molecular cloning and sequencing a Plasmodium chabaudi antigen that is associated with the membrane of the infected erythrocyte throughout the entire intraerythrocytic cycle. The protein (PcEMA1) has a predicted size of 50 kDa and contains a major tandem repeat array of 16 octapeptides that constitutes almost 30% of the protein. At its amino-terminus, PcEMA1 has a string of hydrophobic residues characteristic of a secreted protein, but does not contain a hydrophobic membrane-spanning segment. The antigen appears to reside on the cytoplasmic face of the erythrocytic membrane. PcEMA1 has a predicted pI of 4.4 and is a potential phosphoprotein.

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页码：59 / 68

页数：10

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