HYDROGELS OBTAINED BY RADIATION-INDUCED POLYMERIZATION AS DELIVERY SYSTEMS FOR PEPTIDE AND PROTEIN DRUGS

被引：12

作者：

CARENZA, M ^{[1
]}

LORA, S ^{[1
]}

CALICETI, P ^{[1
]}

SCHIAVON, O ^{[1
]}

VERONESE, FM ^{[1
]}

机构：

[1] UNIV PADUA,CNR,CTR STUDIO CHIM FARM & PROD BIOL ATTIVI,DIPARTIMENTO SCI FARMACEUT,I-35100 PADUA,ITALY

来源：

RADIATION PHYSICS AND CHEMISTRY | 1993年 / 42卷 / 4-6期

关键词：

RADIATION POLYMERIZATION; 2-HYDROXYETHYL METHACRYLATE; HYDROGEL; POLY(HEMA); CONTROLLED RELEASE; PEPTIDE AND PROTEIN RELEASE;

D O I：

10.1016/0969-806X(93)90397-D

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The controlled release of peptides and proteins from hydrogels obtained by radiation-induced polymerization of 2-hydroxyethyl methacrylate at a low temperature was studied. It was found that the extent of release progressively decreased as protein molecular weight increased until no further release occurred above a critical value of the latter. However, an increasing rate of protein release was found if the polymerization was carried out in the presence of poly(ethylene glycol), PEG. Moreover, only with high molecular weight PEGs were large proteins released. The release data as a function of swellability and porosity of polymer matrices were discussed.

引用

页码：897 / 901

页数：5

共 9 条

[1]

CALICETI P, 1992, FARMACO, V47, P275

[2]

CARENZA M, 1992, RADIAT PHYS CHEM, V39, P485

[3]

CARENZA M, 1990, CHIM OGGI, V8, P41

[4] IMMOBILIZATION OF BIOFUNCTIONAL SUBSTANCES [J].