STRUCTURE OF A MODEL FOR THE ARANOROSIN NUCLEUS

被引：3

作者：

HALTIWANGER, RC

EGGLESTON, DS

MCKILLOP, A

TAYLOR, RJK

WATSON, RJ

LEWIS, N

机构：

[1] UNIV E ANGLIA,SCH CHEM SCI,NORWICH NR4 7TJ,NORFOLK,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1994年 / 50卷

关键词：

D O I：

10.1107/S0108270193009266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of a synthetic model system, 2-hydroxy-6,7;9,10-cis,cis-diepoxy-1-oxaspiro[4.5]decan-8-one, C9H10O5, for the spirocyclic headgroup of the natural product aranorosin has been determined and shown to possess the natural product stereochemistry. Two crystallographically independent molecules cocrystallize in a centrosymmetric space group. The syn arrangement of die diepoxides and the lactol O atom about the cyclohexanone ring has been confirmed in both molecules. The cyclohexanone ring adopts a boat conformation with die carbonyl 0 atom anti to the lactol O atom.

引用

页码：274 / 276

页数：3

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