SEVERAL MESSENGER-RNAS WITH VARIABLE 3' UNTRANSLATED REGIONS AND DIFFERENT STABILITY ENCODE THE HUMAN PR264/SC35 SPLICING FACTOR

被引：43

作者：

SUREAU, A ^{[1
]}

PERBAL, B ^{[1
]}

机构：

[1] UNIV PARIS 07,UNITE FORMAT & RECH BIOCHIM,F-75221 PARIS 05,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 03期

关键词：

ALTERNATIVE SPLICING; HEMATOPOIETIC DIFFERENTIATION;

D O I：

10.1073/pnas.91.3.932

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have recently established that several mRNAs encode the PR264/SC35 splicing factor and that their expression is related to that of c-Myb in human hematopoietic cells. We now report that the various PR264 mRNAs whose expression is transactivated by c-Myb proteins encode an identical PR264/SC35 polypeptide. These mRNAs differ only in their 3' untranslated sequences and exhibit significantly different half-lives. We also show that there is a direct correlation between the length of the 3' untranslated region and the stability of the mRNA species. Given that 5' and 3' splice site selection mediated by the PR264/SC35 splicing factor is concentration-dependent, we postulate that alternative splicing of the 3' untranslated sequences might represent another key element in regulating the levels of PR264/SC35 expression during hematopoietic differentiation.

引用

页码：932 / 936

页数：5

共 20 条

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