ANALYSIS OF LIDOCAINE AND ITS DEALKYLATED METABOLITES BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY

被引：16

作者：

WISNICKI, JL ^{[1
]}

TONG, WP ^{[1
]}

LUDLUM, DB ^{[1
]}

机构：

[1] UNION UNIV ALBANY MED COLL,DEPT PHARMACOL & EXPTL THERAPEUT,CLIN PHARMACOL UNIT,ALBANY,NY 12208

来源：

CLINICA CHIMICA ACTA | 1979年 / 93卷 / 02期

关键词：

D O I：

10.1016/0009-8981(79)90100-1

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A high-pressure liquid Chromatographic method is presented for determining lidocaine and its dealkylated metabolites, monoethylglycinexylidide and glycinexylidide, in plasma. This method uses 20-μl samples injected directly through a pre-column onto a C18 analytical column. It is fast, sensitive and linear over a concentration range of 1-10 μg/ml. Since the method requires no preliminary treatment of the plasma, it provides a practical means of monitoring lidocaine and its metabolites in therapeutic situations. © 1979.

引用

页码：279 / 282

页数：4

共 9 条

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