ANTIOXIDANTS REDUCE THE MUTAGENIC EFFECT OF MALONALDEHYDE AND BETA-PROPIOLACTONE .9. ANTIOXIDANTS AND CANCER

被引：119

作者：

SHAMBERGER, RJ

CORLETT, CL

BEAMAN, KD

KASTEN, BL

机构：

[1] The Cleveland Clinic Foundation, Cleveland

来源：

MUTATION RESEARCH | 1979年 / 66卷 / 04期

关键词：

D O I：

10.1016/0165-1218(79)90045-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Increasing concentrations of malonaldehyde and β-propiolactone were increasingly mutagenic with 7 mutants of Salmonella typhimurium, 5 of which mutated by a frameshift mechanism and 2 of which mutated through base-pair substitution. The antioxidants vitamin C, vitamin E, selenium and butylated hydroxytoluene (BHT) at 3 logarithmic concentrations markedly reduced mutagenesis in those strains which mutated by frameshift mechanism. © 1979.

引用

页码：349 / 355

页数：7

共 15 条

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