CHELATION CONTROL IN THE ADDITION OF HOMOPHTHALIC ANHYDRIDE TO ALPHA-ALKOXY IMINES - PANCRATISTATIN MODEL STUDIES

被引：45

作者：

CLARK, RD

SOUCHET, M

机构：

[1] Syntex Research, Institute of Organic Chemistry, Palo Alto, CA 94304

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)94368-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselectivity in the addition of homophthalic anhydride to the α-alkoxy imine (S)-5 can be increased dramatically (to > 90%) with addition of Lewis acids. This methodology has been applied to the synthesis of a model compound (12) which contains four asymmetric centers with the same relative stereochemistry as pancratistatin (1). © 1990.

引用

页码：193 / 196

页数：4

共 13 条

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