P-170 GLYCOPROTEIN, GLUTATHIONE AND ASSOCIATED ENZYMES IN RELATION TO CHEMORESISTANCE OF PRIMARY HUMAN RENAL-CELL CARCINOMAS

被引：26

作者：

MICKISCH, G

BIER, H

BERGLER, W

BAK, M

TSCHADA, R

ALKEN, P

机构：

[1] ENT, Mannheim Hospital, University of Heidelberg, FRG

[2] Department of Cell Biology, Institute of Experimental Pathology, German Cancer Research Center, Heidelberg, FRG

来源：

UROLOGIA INTERNATIONALIS | 1990年 / 45卷 / 03期

关键词：

Glutathione; Human renal cell carcinoma; Multidrug resistance; P-170; glycoprotein;

D O I：

10.1159/000281701

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

High intrinsic chemoresistance contributes to the dismal outcome of patients with disseminated renal cell carcinoma (RCC). In experimental cell lines, two defined defence mechanisms, P-170 glycoprotein and glutathione metabolism, have been established in multidrug resistance, a cross-resistance to cytotoxic compounds without functional or structural similarities. In 21 primary human RCCs, P-170 expression was examined, glutathione content and activities of related enzymes determined and the results were correlated to the degree of in vitro chemoresistance. P-170 was found in 10 of 17 resistant tumors but in none of the sensitive cases. The glutathione content was significantly higher and the related enzyme distinctively enhanced in resistant RCCs. Both mechanisms occurred independently and may well explain the multidrug resistance of RCC. Therefore, reversal of one or both systems may have a clinical impact on the chemotherapy of RCCs. © 1990 S. Karger AG, Basel.

引用

页码：170 / 176

页数：7

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