HYPOTHESIS - THE EFFECT OF ORAL NITRITE ON BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT - DOES DIETARY NITRATE MITIGATE HYPERTENSION AFTER CONVERSION TO NITRITE

被引：42

作者：

CLASSEN, HG ^{[1
]}

STEINHAMMER, C ^{[1
]}

THONI, H ^{[1
]}

机构：

[1] UNIV HOHENHEIM,INST APPL MATH & STAT,W-7000 STUTTGART 70,GERMANY

来源：

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | 1990年 / 9卷 / 05期

关键词：

Blood pressure lowering effects; Hypertensive rats; Nitrite;

D O I：

10.1080/07315724.1990.10720407

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Increasing doses of nitrite (3.7-14.8 mg/kg BW) were administered via intragastric intubation to 64 spontaneously hypertensive Sprague-Dawley rats. Systemic blood pressure, measured in conscious animals with the tail cuff method, significantly decreased in a dose-related manner 16 and 32 minutes later, and pulse rate slightly increased. Since orally ingested nitrate may be partially converted to nitrite, it seems worthwhile to study correlations between dietary nitrate and blood pressure in experimental animals and man. © American College of Nutrition.

引用

页码：500 / 502

页数：3

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