CONCEPT AND DEVELOPMENT OF OPHTHALMIC PSEUDO-LATEXES TRIGGERED BY PH

被引：15

作者：

IBRAHIM, H ^{[1
]}

BINDSCHAEDLER, C ^{[1
]}

DOELKER, E ^{[1
]}

BURI, P ^{[1
]}

GURNY, R ^{[1
]}

机构：

[1] UNIV GENEVA,SCH PHARM,CH-1211 GENEVA,SWITZERLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 77卷 / 2-3期

关键词：

CELLULOSE ACETATE PHTHALATE; ENTERIC POLYMER; POLYACID; SOLUBILITY PARAMETER; PHASE TRANSITION SYSTEM; PSEUDO-LATEX;

D O I：

10.1016/0378-5173(91)90319-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The apparent pK(a), acid value and maximum buffer capacity have been calculated for various polyacids generally utilized for enteric coating, in order to select a polymeric model compound for the preparation of pseudo-latexes triggered by pH for ophthalmic application. The solubility of the selected polymer (cellulose acetate phthalate) was estimated from a ternary plot of its solvents vs fractional solubility parameters. Pseudo-latexes were prepared by emulsification of various organic polymer solutions and removal of the solvents by vacuum distillation. The viscosity behaviour of 30% by weight pseudo-latexes was simulated in vitro to show the sharp and high increase of their viscosity vs pH.

引用

页码：211 / 219

页数：9

共 31 条

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