REVERSAL OF ANTIDEPRESSANT ACTION BY DOPAMINE ANTAGONISTS IN AN ANIMAL-MODEL OF DEPRESSION

被引:93
作者
SAMPSON, D [1 ]
WILLNER, P [1 ]
MUSCAT, R [1 ]
机构
[1] CITY LONDON POLYTECH, DEPT PSYCHOL, OLD CASTLE ST, LONDON E1 7NT, ENGLAND
关键词
STRESS; SUCROSE; SACCHARIN; ANTIDEPRESSANT; DESMETHYLIMIPRAMINE; AMITRIPTYLINE; DOPAMINE; SCH-23390; SULPIRIDE; RAT;
D O I
10.1007/BF02245655
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rats subjected chronically (12 weeks) to a variety of mild, unpredictable stressors showed a reduced consumption of sucrose or a sucrose/saccharin mixture in two-bottle consumption tests (sweet solution versus water). The deficit was apparent within 2 weeks of stress; normal behaviour was restored by chronic (7 weeks) treatment with the tricyclic antidepressants desmethylimipramine (DMI) or amitriptyline (AMI). Acute administration of the dopamine D1 receptor antagonist SCH-23390 1 week after withdrawal, or the dopamine D2 receptor antagonist sulpiride 2 weeks after withdrawal, were without effect in vehicle-treated stressed animals, and in non-stressed animals. However, the DA antagonists selectively reversed the improvement of performance in DMI- or AMI-treated stressed animals. This suggests that an increase in functional activity at DA synapses is the mechanism of action of DMI and AMI in this model.
引用
收藏
页码:491 / 495
页数:5
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