A PRACTICAL, ONE-POT PREPARATION OF DIISOPINOCAMPHEYLCHLOROBORANE

被引：14

作者：

SIMPSON, P

TSCHAEN, D

VERHOEVEN, TR

机构：

[1] Merck Sharp and Dohme Research Laboratories Division of Merck & Co., Inc., Rahway, N. J. 07065

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 15-16期

关键词：

D O I：

10.1080/00397919108021071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc2BCl) from alpha-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful for large scale operations. Asymmetric reduction of ketones using the in situ prepared Ipc2BCl is comparable to that using isolated reagent.

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页码：1705 / 1714

页数：10

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